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KMID : 1094020210380030105
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Journal of Veterinary Clinics
2021 Volume.38 No. 3 p.105 ~ p.114
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Intra-Articular Injection of High-Dose ELHLD Peptide for Managing Canine Stifle Osteoarthritis: Kinetic Gait Analysis
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Jeong Na-Rae
Kang Byung-Jae
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Abstract
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Intra-articular injection of ELHLD peptide is considered to have a therapeutic effect in osteoarthritis (OA) through the inhibition of transforming growth factor-β1. This study aimed to assess the efficacy of intra-articular injections of high-dose ELHLD peptide (100 ㎍/kg) in canine stifle OA. Six client-owned dogs diagnosed with stifle OA were included. Selected dogs were treated with an intra-articular injection of high-dose ELHLD peptide (100 ㎍/kg). Outcome measures, including orthopedic examination, gait analysis, and Canine Brief Pain Inventory (CBPI) score, were evaluated four times after injection. Orthopedic examination, gait analysis, and owner's assessment (CBPI) improved significantly from 4 weeks after injection. In conclusion, we obtained sufficient evidence from this small sample that high-dose ELHLD peptide improves clinical signs of canine OA not only through subjective assessment but also through objective evaluation.
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KEYWORD
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dog, ELHLD peptide, osteoarthritis, kinetic gait analysis, stifle joint
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